Increased secretion acetylcholine by the Panax ginseng cause induced insulin secretion in rats.
Trials will be used rats that starving let it get the panax ginseng by feeding. It was found that after feeding for 90 minutes, blood glucose levels of rats decline by effect is dependent on the amount of this herbal from feeding. Which reduced level of sugar in the blood, it coincides with the increased levels of insulin and C-peptide in blood.
In trials it was found that if annoy the acetylcholine generating. Either by inhibition of choline uptake (hemicholinium-3) or vesicular choline transport (vesamicol). It will inhibit metabolic action of the panax ginseng. On the other hand, if using Physostigmine, which inhibits the acetylcholinesterase enzyme, it makes the effect of ginseng increases. It is possible that the effect of this herb root secretions acetylcholine of nerve endings when induced to secrete insulin and inhibitory effect of ginseng by 4-diphenylacetoxy-N-methylpiperdine methiodide (compound inhibits muscarinic M3 receptor), it helps to support that the effect of this root occurs at muscarinic M3 receptor.